Tetrapyrroles and derivatives
Abcam Dorsomorphin (Compound C), AMP-kinase inhibitor, 10MG
MW 399.5 Da, Purity >99%. Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable. Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821).
The product is subject to the following: Abcam Restricted Use Statement
eMolecules 3-Aminodihydrofuran-2(3H)-one hydrochloride | 42417-39-0 | MFCD27977179 | 1g
Ambeed | 3-Aminodihydrofuran-2(3H)-one hydrochloride | 1g | 525096753 | A179518 | | 42417-39-0 | MFCD27977179 | 137.560 | C4H8ClNO2
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Abcam Zaprinast, cGMP phosphodiesterase inhibitor, 10MG
MW 271.28 g/mol, Purity >98%. Specific cGMP phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC₅₀ values are 0.15 (PDE6), 0.76 (PDE5), 12 (PDE11) and 29 μM (PDE9)). Reputed GPR35 agonist (EC₅₀ values are 16 and 840 nM at rat and human GPR35 receptors, respectively). Important mediator for a variety of cellular processes including vasodilation.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PD 168568 dihydrochloride, D4 antagonist, 10MG
MW 422.4 g/mol, Purity >99%. Potent and selective D₄ antagonist (Ki = 8.8 nM at D₄, and 1842 nM at D₂). Inhibits amphetamine stimulated locomotor activity in vivo; orally active.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GsMT x -4, mechanosensitive and stretch-activated ion channel inhibitor, 100UG
MW 4096 Da. GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Sigma Aldrich Fine Chemicals Biosciences Cytochrome c from bovine heart | 9007-43-6 | MFCD00130890 | 250 mg
Cytochrome c from bovine heart | Purity: ≥95% | Mol Wt: 12327 Da | 9007-43-6 | MFCD00130890 | 250 mg
Sigma Aldrich Fine Chemicals Biosciences Cytochrome c from equine heart suitable for GFC marker, BioReagent | 9007-43-6 | MFCD00130890 | 1VL
Cytochrome c from equine heart suitable for GFC marker, BioReagent | 9007-43-6 | MFCD00130890 | 1VL
Abcam GM 6001, MMP inhibitor, 5MG
MW 388.5 Da, Purity >98%. Broad spectrum potent MMP inhibitor. Ki values are 0.4 (MMP-1), 0.5 (MMP-2), 27 (MMP-3), 0.1 (MMP-8), 0.2 (MMP-9), 13.4 (MMP-14) and 0.36 (MMP-26) nM. IC₅₀ value for MMP-7 is 3.7 nM. Pharmacologically active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CHIR99021, GSK3 inhibitor, 5MG
MW 465.3 Da, Purity >98%. Potent, highly selective aminopyrimidine GSK3 inhibitor (IC₅₀ values are 6.7 and 10 nM at GSK3β and GSK3α, respectively). Exhibits >500-fold selectivity for GSK3 against 20 closely related protein kinases and >800-fold selectivity for 23 additional enzymes and 22 receptors. Promotes self-renewal of mouse and human ESC due to β-catenin and c-Myc protein level stabilization. Commonly used in multiple stages of organoid generation.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Endothelin-1 (human, porcine), Vasoconstrictor peptide, 10UG
MW 2491.9 Da. Endothelin-1 (human, porcine), Vasoconstrictor peptide. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam WAY-100635 maleate, 5-HT1A receptor antagonist, 50MG
MW 538.6 Da, Purity >98%. Potent, selective, silent 5-HT1A receptor antagonist (IC50 = 1.35 nM). Displays >100-fold selectivity for 5-HT1Arelative to a range of other CNS receptors including other 5-HT subtypes, adrenoceptors, dopamine, GABA, histamine and ion channels. Binds selectively to rodent brain 5-HT1A receptors *in vivo* (iv admin). Unlike WAY100135, WAY100635 displays no partial agonist activity in the ventral hippocampus of rats.
The product is subject to the following: Abcam Restricted Use Statement